Abstract |
The effects of gossypol on liver metabolism were examined in male rats. Gossypol acetic acid was administered to Sprague-Dawley rats intraperitoneally (i.p.) at 5 mg/kg daily, 5 days/week for 2 weeks. The rats were killed 24 h after the last injection. The liver/ body weight ratio (-42%), concentration of liver glutathione (-34%), activities of liver alpha-naphthtylacetate esterase (-30%) and DNase (-39%) were significantly decreased when compared to controls. Hepatic beta-glucuronidase (+37%), RNase (+35%) and serum alkaline RNase (+23%) activities were significantly increased. No changes were found in serum transaminases ( SGPT, SGOT) or in hepatic RNA and DNA concentration. Elevation of liver and serum RNase activities suggest that gossypol treatment produces some catabolic effects. The depletion of hepatic glutathione and the elevation of beta-glucuronidase activity indicate that gossypol is hepatotoxic when given at this dose for 2 weeks.
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Authors | S F Ali, S M El-Sewedy |
Journal | Toxicology letters
(Toxicol Lett)
Vol. 23
Issue 3
Pg. 299-306
(Dec 1984)
ISSN: 0378-4274 [Print] Netherlands |
PMID | 6084346
(Publication Type: Journal Article)
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Chemical References |
- RNA
- DNA
- Aspartate Aminotransferases
- Alanine Transaminase
- Deoxyribonucleases
- Naphthol AS D Esterase
- Ribonucleases
- Glucuronidase
- Glutathione
- Gossypol
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Aspartate Aminotransferases
(blood)
- DNA
(metabolism)
- Deoxyribonucleases
(metabolism)
- Glucuronidase
(metabolism)
- Glutathione
(metabolism)
- Gossypol
(pharmacology)
- Liver
(drug effects, enzymology)
- Male
- Naphthol AS D Esterase
(metabolism)
- RNA
(metabolism)
- Rats
- Rats, Inbred Strains
- Ribonucleases
(metabolism)
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