[Experimental study of the interferonogenic and antiviral activity of biologically active substances].

Abstract

The results of screening of five national preparations for the interferon-inducing activity in white mice by various doses, schedules and routes of administration are presented. Their capacity to protect the animals against influenza, tick-borne encephalitis, and herpes viruses was evaluated. Cuthizon, zimosan, tiloron and its analogue IC-32 induced in mice endogenous interferon production in amounts from 40 to 640 IU50/ml. Tiloron, prodigiozin, and zimosan were found to be effective against influenza. Protective effect of zimosan in combination with polyguacyl was observed against tick-borne encephalitis.

• Authors: I B Kremerman, L S Priĭmiagi, F I Ershov
• Journal: Voprosy virusologii (Vopr Virusol) 1984 Sep-Oct Vol. 29 Issue 5 Pg. 549-53 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'noe izuchenie interferonogennoĭ i protivovirusnoĭ aktivnosti nekotorykh biologicheski aktivnykh veshchestv.
• PMID: 6083669 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antiviral Agents
• Interferon Inducers
• Polysaccharides, Bacterial
• Interferons

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Antiviral Agents (pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Drug Synergism
• Encephalitis, Tick-Borne (drug therapy)
• Herpes Simplex (drug therapy)
• Interferon Inducers (pharmacology, therapeutic use)
• Interferons (blood)
• L Cells (microbiology)
• Mice
• Orthomyxoviridae Infections (drug therapy)
• Polysaccharides, Bacterial (pharmacology)
• Time Factors
• Virus Cultivation