[Cerebrospinal fluid melatonin in diseases of the nervous system].

Abstract

In 66 patients with some diseases of the nervous system (epilepsy, brain tumors, traumatic brain lesions, discorgenic lumbosacral radiculitis) melatonin content in liquor was determined by a fluorimetric method, especially modified for this purpose. The increase of melatonin concentration in liquor mostly significant in frequent epileptic strokes was found. In brain tumors the hormone content depended upon the severity of the patients' state, the existence of epileptic strokes, brain stem and hypothalamus involvement into the process. In traumatic subarachnoid hemorrhages, in the hypothalamic syndrome, the melatonin content was very high. An assumption on melatonin defensive role in conditions of the nervous system pathology and the topico-diagnostical significance of its study in liquor is made.

• Authors: A Iu Makarov, V N Kiselev, E B Loboda
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 77 Issue 12 Pg. 1814-6 ( 1977) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Melatonin likvora pri zabolevaniiakh nervnoĭ sistemy.
• PMID: 602555 (Publication Type: English Abstract, Journal Article)

Chemical References

• Melatonin

Topics

• Adolescent
• Adult
• Arachnoiditis (cerebrospinal fluid)
• Brain Diseases (cerebrospinal fluid)
• Brain Injuries (cerebrospinal fluid)
• Brain Neoplasms (cerebrospinal fluid)
• Epilepsy (cerebrospinal fluid)
• Female
• Humans
• Intervertebral Disc Displacement (cerebrospinal fluid)
• Male
• Melatonin (cerebrospinal fluid)
• Middle Aged