[Effect of hexahydroubiquinone-4 (KoQ4) on the bioenergetics and functional activity of the myocardium in ischemia].

Abstract

The effect of KoQ4 on the energetics, contractility, and electrogram of the ischemized myocardium was studied in acute experiments on dogs with induced myocardial ischemia. Intracornoary administration of KoQ4, 1.3 mg/kg, directly into the focus of ischemia for 15 min promoted a decrease in the lactate level in blood draining from the ischemic zone as compared to the control data in the absence of a difference in the dynamics of the pyruvic acid content. In distinction to the control experimental series, there was no decrease in the concentration of glucose in samples of venous blood draining from the focus of ischemia. Under the effect of KoQ4 the amplitude of left ventricular pressure and the maximum rate of its growth (dp/dt) increased moderately and the ST segment and ST/R coefficient of the epicardial electrogram from the border zone of ischemia decreased. It was shown in the rat experiments that preliminary intravenous administration of KoQ4 (14 mg/kg) increased myocardial resistance to oxygen deficiency under conditions of diacetylcholine-induced apnoe.

• Authors: V V Pichugin, E A Obol'nikova, G I Samokhvalov, V V Gatsura
• Journal: Kardiologiia (Kardiologiia) Vol. 17 Issue 12 Pg. 79-83 (Dec 1977) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Vliianie geksagidroubikhinona-4 (KoQ4) na bioénergetiku i funktsional'nuiu aktivnost' miokarda pri ishemii.
• PMID: 599831 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Lactates
• Pyruvates
• Ubiquinone
• hexahydroubiquinone-4

Topics

• Acute Disease
• Animals
• Blood Glucose (analysis)
• Blood Pressure (drug effects)
• Coronary Disease (drug therapy, physiopathology)
• Dogs
• Drug Evaluation, Preclinical
• Energy Metabolism (drug effects)
• Heart (drug effects, physiopathology)
• Heart Rate (drug effects)
• Lactates (blood)
• Myocardial Contraction (drug effects)
• Myocardium (metabolism)
• Pyruvates (blood)
• Time Factors
• Ubiquinone (analogs & derivatives, pharmacology)