HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Alopecia induced by inhalation exposure to phenyl glycidyl ether.

Abstract
Rats and dogs were exposed to heated phenyl glycidyl ether (310 degrees C) vapor at average levels of 1.3, 5.0, and 11.8 ppm (v/v) for 6 hr/day, 5 days/wk, for 90 days. No adverse effects were observed in the dogs and rats other than alopecia in rats at the dose levels of 5.0 and 11.8 ppm. Microscopically, the skin lesions revealed slight acanthosis, hyperkeratosis, and occasional patchy parakeratosis in the epidermis. Follicular keratin plugs were observed with hyperkeratosis of epithelium in the hair follicles and sebaceous glands. Inflammatory reaction was mainly confined to the perifollicular region and affected the hair follicles, resulting in atrophy. The number of hair follicles in the resting stage appeared to increase. The hair shafts revealed impairment of keratinization and fragmentation. Extracted hairs showed an increase in the number of dystrophic follicles and constricted or broken hair shafts.
AuthorsK P Lee, J B Terrill, N W Henry 3rd
JournalJournal of toxicology and environmental health (J Toxicol Environ Health) Vol. 3 Issue 5-6 Pg. 859-69 (Dec 1977) ISSN: 0098-4108 [Print] United States
PMID599584 (Publication Type: Journal Article)
Chemical References
  • Epoxy Compounds
  • Pharmaceutic Aids
  • Phenyl Ethers
  • phenylglycidyl ether
Topics
  • Alopecia (chemically induced, pathology)
  • Animals
  • Dogs
  • Drug Stability
  • Environmental Exposure
  • Epoxy Compounds (toxicity)
  • Hair (drug effects, ultrastructure)
  • Microscopy, Electron, Scanning
  • Pharmaceutic Aids (toxicity)
  • Phenyl Ethers (toxicity)
  • Rats
  • Skin (drug effects, ultrastructure)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: