[Studies of sulfhemoglobin formation by various drugs (3) (author's transl)].

Abstract

Sulfhemoglobin (SHb) and methemoglobin (MHb) formations by various compounds were examined by single and three consecutive intraperitoneal administrations to mice. With a single administration, methemoglobinemia was induced by diphenylamine (DPA), 1-naphthylamine (NA), phenylnaphthylamine (PNA), N-(1-naphthyl) anthranilic acid (N1) and N-(1'-naphthyl)-2-aminophenylacetic acid (IG240), and was not observed with phenylanthranilic acid (PAA), N-benzoyl-N'-phenyl-2, 6-diaminobenzoic acid (BPAA), flufenamic acid (FA), mefenamic acid (MFA), N-(2-6-dichlorophenyl) anthranilic acid (CPAA), N-(2', 6'-dichlorophenyl)-2-aminophenylacetic acid (CPPA), nine derivatives of N1 and two derivatives of IG240. On the other hand, sulfhemoglobinemia, with a single administration, was found to be induced by NA. Furthermore, with three consecutive administrations, such was induced by DPA, PAA, BPAA and FA even though SHb was not demonstrated with a single administration, and was not observed with MF, CPAA, CPPA and various derivatives of N1 and IG240.

• Authors: A Nomura
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 73 Issue 7 Pg. 793-802 (Oct 1977) ISSN: 0015-5691 [Print] Japan
• PMID: 598785 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aniline Compounds
• Naphthalenes
• Phenylacetates
• ortho-Aminobenzoates
• Methemoglobin
• Sulfhemoglobin
• 1-Naphthylamine
• Diphenylamine

Topics

• 1-Naphthylamine (administration & dosage, analogs & derivatives, pharmacology)
• Aniline Compounds (pharmacology)
• Animals
• Diphenylamine (administration & dosage, pharmacology)
• Male
• Methemoglobin (biosynthesis)
• Mice
• Naphthalenes (analogs & derivatives)
• Phenylacetates (administration & dosage, pharmacology)
• Structure-Activity Relationship
• Sulfhemoglobin (biosynthesis)
• Time Factors
• ortho-Aminobenzoates (administration & dosage, pharmacology)