[Diagnosis of anticonvulsant osteomalacia in adults (author's transl)].

Abstract

In 100 epileptic patients under treatment with long-term anti-convulsants, radiographs of the hands and feet, and estimations of serum 25-hydroxycholecalciferol, parathormone, alkaline phosphatase, calcium, and inorganic phosphate were done to detect a medication-induced osteomalacia. The correlation between the individual parameters was investigated. It was shown that the serum 25-hydroxycholecalciferol level and the skeletal radiograph were the most valuable in the early detection of osteomalacia. One of these investigations in addition to routine serum chemistry is recommended for the future at the yearly follow-up examinations of adult epileptics so that early and adequate treatment with vitamin D can be started.

• Authors: K H Krause, P Prager, H Schmidt-Gayk, E Ritz
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 102 Issue 51 Pg. 1872-7 (Dec 23 1977) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Diagnostik der Osteopathia antiepileptica im Erwachsenenalter.
• PMID: 598289 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Hydroxycholecalciferols
• Parathyroid Hormone
• Phosphates
• Vitamin D
• Alkaline Phosphatase
• Calcium

Topics

• Adolescent
• Adult
• Aged
• Alkaline Phosphatase (blood)
• Anticonvulsants (administration & dosage, adverse effects)
• Calcium (blood)
• Female
• Humans
• Hydroxycholecalciferols (blood)
• Male
• Middle Aged
• Osteomalacia (blood, chemically induced, diagnostic imaging, drug therapy)
• Parathyroid Hormone (blood)
• Phosphates (blood)
• Radiography
• Time Factors
• Vitamin D (therapeutic use)