[Antitumor effect of glycopeptides from the cell wall of Lactobacillus bulgaricus].

Abstract

The antitumor activity of "blastolysin", a preparation that consisted mainly of glycopeptide fragments of the cell wall of Lactobacillus bulgaricus, was studied. Blastolysin was found to exert a specific antitumor effect on sarcoma S-180, leukemia P-388, plasmacytoma MOPC-315, adenocarcinoma AKATOL, melanosarcoma B-16, carcinoma LIC, and spontaneous tumors in mice. It is of low toxicity, does not inhibit hemopoiesis, and its action on tumor tissue differs considerably from that of the known antitumor chemotherapeutic agents.

• Authors: I G Bogdanov, V T Velichkov, A I Gurevich, P G Dalev, M N Kolosov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 84 Issue 12 Pg. 709-12 (Dec 1977) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Protivoopukholovoe deĭstvie glikopeptidov kletochnoĭ stenki Lactobacillus bulgaricus.
• PMID: 597607 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Glycopeptides

Topics

• Animals
• Antineoplastic Agents
• Cell Wall (analysis)
• Glycopeptides (isolation & purification, therapeutic use)
• Lactobacillus (analysis)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Neoplasms, Experimental (drug therapy)