[Secretion of a beta lipotropine type substances by a corticomelanotropic adenoma in Nelson's syndrome (author's transl)].

Abstract

Using radioimmunoassay of human melanotropic hormone (beta-MSH), were studied in one female patient with Nelson's syndrome the properties of the immunoreactive beta-MSH (beta-MSH-IR) secreted in the circulation in vitro by a pituitary adenoma. With Sephadex G-50 gel, beta-MSH-IR of plasma or from a culture mediium is eluted in greater part in a volume corresponding to a molecular weight of some 6,000 to 10,000. In the radioimmunological systems employed, the dilution curve of beta-MSH-IR in a culture medium is not parallel to that of synthetic human beta-MSH; by contrast, it is parallel to that a lipotropine, purified human beta-LPH.

• Authors: X Bertagna, J P Luton, M Donnadieu, M Binoux, F Girard, H Bricaire
• Journal: La Nouvelle presse medicale (Nouv Presse Med) Vol. 6 Issue 36 Pg. 3299-303 (Oct 29 1977) ISSN: 0301-1518 [Print] France
• Vernacular Title: Sécrétion d'une substance "de type beta-lipotropine" par un adénome cortico-mélanotrope au cours d'un syndrome de Nelson.
• PMID: 593850 (Publication Type: Case Reports, Journal Article)

Chemical References

• Melanocyte-Stimulating Hormones
• beta-Lipotropin

Topics

• Adenoma (metabolism)
• Adult
• Chromatography, Gel
• Cross Reactions
• Female
• Humans
• Melanocyte-Stimulating Hormones (metabolism)
• Nelson Syndrome (metabolism)
• Pituitary Neoplasms (metabolism)
• Time Factors
• beta-Lipotropin (metabolism)