Possible use of phosphohexose isomerase as a preliminary to exfoliative cytology in screening for cervical carcinoma.

Abstract

The activities of phosphohexose isomerase and 6-phosphogluconate dehydrogenase have been studied in the vaginal fluid of women from the gynaecological departments. Women from these departments gave a very high false positive rate, though no cases of carcinoma in situ were not detected by estimating phosphohexose isomerase levels. It gave considerably better results in malignancy than 6-phosphogluconate dehydrogenase. It is suggested that the use of phosphohexose isomerase might be of value in screening well women during a mass cytology programme.

• Authors: G G Muir
• Journal: Journal of clinical pathology (J Clin Pathol) Vol. 19 Issue 4 Pg. 378-83 (Jul 1966) ISSN: 0021-9746 [Print] England
• PMID: 5929340 (Publication Type: Journal Article)

Chemical References

• Glucose-6-Phosphate Isomerase

Topics

• Cytodiagnosis
• Female
• Glucose-6-Phosphate Isomerase (analysis)
• Humans
• Mass Screening
• Uterine Cervical Neoplasms (diagnosis)
• Vagina (enzymology)