Abstract |
The absorption and tissue distribution of ochratoxin A (OCT A) following a single oral dose of OCT A were investigated in adult, male Wistar rats. In experiments concerning excretory patterns of OCT A, 14C-OCT A was used. A relatively large amount of OCT A was found in the circulating blood 48 hours after dosing. The patterns of absorption, tissue distribution and excretion of OCT A were affected by acute catarrhal enteritis produced by OCT A and/or ochratoxin alpha(OCT alpha). Quantitative data show that OCT A is distributed mostly in the kidney and this finding is closely associated with the tissue specifity of OCT A-induced nephrotoxicity. OCT A was found to be hydrolyzed to its major metabolite, OCT alpha by addition of the homogenate of pancreas, duodenum and ileum. Approximately 56% of OCT A administered was excreted in both urine and feces as the unchanged toxin and OCT alpha during 120 hours following dosing. A relatively larger amount of OCT alpha was detected as compared with that of OCT A.
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Authors | S Suzuki, T Satoh, M Yamazaki |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 27
Issue 5
Pg. 735-44
(Oct 1977)
ISSN: 0021-5198 [Print] Japan |
PMID | 592561
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Bile
(analysis)
- Digestive System
(metabolism)
- Enteritis
(chemically induced)
- Hydrolysis
- Kinetics
- Male
- Ochratoxins
(metabolism)
- Rats
- Tissue Distribution
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