Synthesis of carboxyarylindoles and benzofurans as nonsteroidal antiinflammatory agents.

Abstract

2-Carboxyaryl-substituted dihydrobenz[e]indoles, tetrahydroindoles, and tetrahydrobenzofurans have been synthesized as structural analogues of fendosal, a new antiinflammatory agent, and tested in the carrageenan-induced rat paw edema assay. Two of these, 2-(3-carboxy-4-hydroxyphenyl)-3-phenyl-4,5-dihydrobenz[e]indole and 1-(n-butyl)-2-(3-carboxy-4-hydroxyphenyl)-4,5,6,7-tetrahydroindole, were found to have significant activity, albeit of a lower order than fendosal.

• Authors: R C Effland
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 20 Issue 12 Pg. 1703-5 (Dec 1977) ISSN: 0022-2623 [Print] United States
• PMID: 592341 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Benzofurans
• Indoles

Topics

• Animals
• Anti-Inflammatory Agents (chemical synthesis)
• Benzofurans (chemical synthesis, pharmacology)
• Edema (physiopathology)
• Indoles (chemical synthesis, pharmacology)
• Male
• Rats
• Structure-Activity Relationship