| Abstract | Twenty-six patients affected by Parkinson's disease were treated with a 2-Br-alpha-ergocriptine (CB 154): 14 cases were given CB 154 alone, and 12 were given CB 154 along with L-dopa plus benserazide (Madopar). Both CB 154 and combined therapy (CB 154+Madopar) induced a significant improvement in total disability score, tremor, rigidity, akinesia, self-sufficiency, and some motor performance tests (dynamic tests). No significant difference was found between results obtained with CB 154 therapy and with Madopar treatment, while the improvement induced by combined therapy (CB 154+Madopar) was significantly higher than that obtained by Madopar alone. The averse reactions caused by CB 154 alone or associated with Madopar are similar to those observed during other dopaminergic treatment. CB 154 alone or combined with Madopar appears to be a useful advance in the management of Parkinson's disease. |
| Authors | T A Caraceni, I Celano, E Parati, F Girotti |
| Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 40
Issue 12
Pg. 1142-6
(Dec 1977)
ISSN: 0022-3050 ENGLAND |
| PMID | 591982
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
- Hydrazines
- Levodopa
- Bromocriptine
- Benserazide
|
| Topics |
- Aged
- Benserazide
(adverse effects, therapeutic use)
- Bromocriptine
(adverse effects, therapeutic use)
- Drug Evaluation
- Drug Therapy, Combination
- Female
- Humans
- Hydrazines
(therapeutic use)
- Levodopa
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Parkinson Disease
(drug therapy)
|
