Adenovirus multiplication: inhibition by methisazone.

Abstract

Methisazone (5 to 40 microM) inhibited the multiplication of types 3, 7, 9, 11, 14, 16, 17, 21, and 28 adenovirus; SV15 (a simian adenovirus) was also inhibited. A study of adenovirus 11 under single-cycle conditions showed that multiplication of the virus, was completely inhibited by 30 microM methisazone when addition of the compound was delayed until 13 hours after infection. A survey showed that the structure-activity relations of the action of methisazone against adenoviruses and pox viruses are similar.

• Authors: D J Bauer, K Apostolov
• Journal: Science (New York, N.Y.) (Science) Vol. 154 Issue 3750 Pg. 796-7 (Nov 11 1966) ISSN: 0036-8075 [Print] United States
• PMID: 5919452 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiviral Agents
• Thiosemicarbazones
• Idoxuridine

Topics

• Adenoviridae (drug effects)
• Antibody Formation (drug effects)
• Antiviral Agents (pharmacology)
• Culture Techniques
• HeLa Cells
• Idoxuridine (pharmacology)
• Poxviridae (drug effects)
• Thiosemicarbazones (pharmacology)