The effects of d-amphetamine and temperature on p-cresol and pentylenetetrazol induced convulsions.

Abstract

Each of twelve (12) rats were subjected to temperatures of 37c, 20c, and 4c in an environmental chamber. Seizure responses to p-cresol injections produced a U-shaped function, with minimal seizures occuring at 20c. Subsequent administration of d-amphetamine eliminated seizures, except at 4c, at which temperature only stereotyped behavior was observed. Environmental temperature effects on metrazol injections in a second group (N=72) seemed to increase linearly with respect to seizure susceptibility and mortality, although latency to first seizure was also a U-shaped function. The findings are discussed in the context of developing a model of epilepsy appropriate for behavioral research.

• Authors: S Yehuda, R L Carasso
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 7 Issue 4 Pg. 223-6 ( 1977) ISSN: 0020-7454 [Print] England
• PMID: 591196 (Publication Type: Journal Article)

Chemical References

• Cresols
• Dextroamphetamine
• Pentylenetetrazole

Topics

• Animals
• Body Weight
• Cresols
• Dextroamphetamine (pharmacology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Male
• Pentylenetetrazole
• Rats
• Reaction Time
• Seizures (chemically induced, drug therapy, mortality)
• Temperature