Cyclic peptides. II. Synthesis of AM-Toxin I.

Abstract

To confirm the structure of AM-toxin I (a phytotoxic cyclotetradepsipeptide) the proposed peptide was prepared by a conventional method. The synthetic peptide and natural AM-toxin I were identical as regards t.l.c., u.v., mass spectra and biological activity in causing necrosis on apple leaves. A prepared dimer of AM-toxin I showed extremely weak activity; the relationship between the ring size and biological activity of AM-toxin I is discussed.

• Authors: Y Shimohigashi, S Lee, H Aoyagi, T Kato, N Izumiya
• Journal: International journal of peptide and protein research (Int J Pept Protein Res) Vol. 10 Issue 4 Pg. 323-7 (Oct 1977) ISSN: 0367-8377 [Print] Denmark
• PMID: 591181 (Publication Type: Journal Article)

Chemical References

• Peptides, Cyclic
• Toxins, Biological

Topics

• Mass Spectrometry
• Methods
• Peptides, Cyclic (chemical synthesis)
• Plants (drug effects)
• Spectrophotometry, Ultraviolet
• Toxins, Biological (chemical synthesis)