Immunochemical study of antigenic specificity in delayed hypersensitivity. IV. The production of unresponsiveness to delayed hypersensitivity with a single antigenic determinant.

Abstract	Injections of various conjugates of arsanilic acid into newborn guinea pigs produced a specific tolerance in respect to subsequent development of hapten-specific delayed hypersensitivity. In general, larger polyvalent conjugates produced longer lasting and more profound suppression of delayed sensitivity than did the smaller ones. Carrier injections alone were ineffective. At lower doses of conjugate, breakthrough of tolerance occurred first with animals immunized with the heterologous carrier conjugate. The duration of tolerance produced by injection of monovalent conjugates into neonates is in contrast to the transient inhibition produced by the same conjugates in previously sensitized animals, suggesting that different target cells may be involved in these two phenomena.
Authors	V E Jones, S Leskowitz
Journal	The Journal of experimental medicine (J Exp Med) Vol. 122 Issue 3 Pg. 505-15 (Sep 01 1965) ISSN: 0022-1007 [Print] United States
PMID	5839283 (Publication Type: Journal Article)
Chemical References	Antigens Arsenicals Peptides Serum Albumin Serum Albumin, Bovine
Topics	Animals Animals, Newborn Antigens Arsenicals (pharmacology) Guinea Pigs Hypersensitivity, Delayed (etiology) Immune Tolerance Immunochemistry Peptides (pharmacology) Serum Albumin (pharmacology) Serum Albumin, Bovine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!