HLA in primary atrophic hypothyroidism and Hashimoto goitre.

Abstract

The prevalence of HLA-B8 was found to be significantly increased in patients with primary atrophic (no goitre) hypothyroidism, but not in goitrous patients with Hashimoto thyroiditis, whether euthroid or hypothroid. There was no correlation between the occurrence of HLA-B8 and the presence of titres of thyroid antibodies at diagnosis or their persistence for at least three years after diagnosis.

• Authors: W J Irvine, R S Gray, P J Morris, A Ting
• Journal: Journal of clinical & laboratory immunology (J Clin Lab Immunol) Vol. 1 Issue 3 Pg. 193-5 (Nov 1978) ISSN: 0141-2760 [Print] Scotland
• PMID: 583053 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• HLA Antigens
• Thyroglobulin

Topics

• Adult
• Aged
• Autoantibodies
• Autoimmune Diseases (immunology)
• Female
• HLA Antigens
• Humans
• Hypothyroidism (immunology)
• Male
• Microsomes (immunology)
• Middle Aged
• Thyroglobulin (immunology)
• Thyroid Gland (immunology)
• Thyroiditis, Autoimmune (immunology)