Abstract |
Twelve patients with duodenal ulcers were each given on separate days and in random order an oral local anaesthetic ( oxethazaine), an alkali ( aluminium hydroxide and magnesium hydroxide), a combination of local anaesthetic and alkali ( Mucaine), and a similar volume of water (control) followed one hour later by a solution of meat extract (Oxo). The effect of these treatments on serum gastrin levels was measured. None of the treatments altered the normal basal gastrin levels. The gastrin response to ingestion of protein extract was significantly lower in patients who had been pre-treated with local anaesthetic than those who had received alkali, with or without local anaesthetic, or water.
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Authors | G O Barbezat, A I Vinik, B Grant |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 13
Issue 3
Pg. 321-3
( 1978)
ISSN: 0036-5521 [Print] England |
PMID | 582628
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Alkalies
- Anesthetics, Local
- Dietary Proteins
- Ethanolamines
- Gastrins
- Aluminum Hydroxide
- Magnesium Hydroxide
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Topics |
- Administration, Oral
- Adult
- Alkalies
(administration & dosage, pharmacology)
- Aluminum Hydroxide
(pharmacology)
- Anesthetics, Local
(administration & dosage, pharmacology)
- Dietary Proteins
(administration & dosage)
- Drinking
- Duodenal Ulcer
(blood)
- Ethanolamines
(pharmacology)
- Gastrins
(blood)
- Humans
- Magnesium Hydroxide
(pharmacology)
- Meat
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