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Formation of asbestos bodies under the influence of parenteral iron overload.

Abstract
The effect of parenteral administration of iron (dextran) on the number of asbestos fibers in the lungs, formation of asbestos bodies and the development of interstitial fibrosis was studied in guinea pigs exposed intratracheally to anthophyllite dust. The treatment did not accelerate, either qualitatively or quantitatively, the formation of asbestos bodies or retard the development of interstitial fibrosis. The number of naked asbestos fibers was also similar in anthophyllite-inoculated animals to those similarly inoculated, but having had, additionally, a previous saturation with iron.
AuthorsS Narang, J L Kaw, S H Zaidi
JournalActa pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 42 Issue 5 Pg. 337-42 (May 1978) ISSN: 0001-6683 [Print] Denmark
PMID581028 (Publication Type: Journal Article)
Chemical References
  • Iron
Topics
  • Animals
  • Asbestosis (etiology, pathology)
  • Female
  • Guinea Pigs
  • Iron (pharmacology)
  • Liver (pathology)
  • Lung (pathology)
  • Pulmonary Fibrosis (etiology)

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