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Effects of guanadrel on patients with thyrotoxicosis.

Abstract
Eleven patients with Graves' disease were treated with guanadrel sulfate and observed for changes in neuromuscular and cardiovascular manifestations. No notable changes in pulse rate or muscle strength were detected in either these patients during a three-day pretreatment period or in five control patients with Graves' disease receiving placebo for six days. Thyroid hormone levels were not altered by seven days of guanadrel sulfate therapy (5 to 20 mg orally every six hours), and no adverse side effects were encountered. Mean supine resting pulse fell from 102 +/- 6 (mean +/- SEM) to 90 +/- 3 beats per minute (P less than .02). The patients' proximal and distal muscle strengths were initially decreased, when compared with healthy subjects, and improved substantially with guanadrel therapy. We conclude that guanadrel sulfate may be useful in the symptomatic management of patients with thyrotoxicosis.
AuthorsS Rubenfeld, B M Patten, P O Kohler
JournalArchives of internal medicine (Arch Intern Med) Vol. 138 Issue 7 Pg. 1106-8 (Jul 1978) ISSN: 0003-9926 [Print] United States
PMID580863 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Guanidines
  • Spiro Compounds
  • guanadrel
Topics
  • Adult
  • Drug Evaluation
  • Female
  • Graves Disease (drug therapy)
  • Guanidines (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Muscles (drug effects)
  • Posture
  • Pulse (drug effects)
  • Spiro Compounds (therapeutic use)

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