Comparison of the hypotensive and diuretic effects of 1,4-dimorpholino-7-phenylpyrido[3,4]pyridazine (DS-511) and hydrochlorothiazide in Doca, renal and spontaneously hypertensive rats.

Abstract

The hypotensive and diuretic activities of a new diuretic, 1,4-dimorpholino-7-phenylpyrido[3,4-d] pyridazine (DS-511), were compared with those of hydrochlorothiazide (HC) in DOCA, renal and spontaneously hypertensive rats. The results obtained were: 1. During the developing stage of DOCA-hypertension the daily treatment of rats with DS-511 and HC showed significant hypotensive action. During this period the diuretic activity of both agents was clear. 2. During the equilibrium stage of DOCA-hypertension the hypotensive action of DS-511 was indistinct despite its diuretic activity. The hypotensive and diuretic action of HC was not clear. 3. In renal-hypertensive rats the daily treatment of DS-511 and HC caused significant, but weaker hypotension than that in the developing stage of DOCA-hypertension. In these animals the diuretic activity of both agents was clear. 4. In spontaneously hypertensive rats the daily treatment with DS-511 and HC exhibited a similar hypotensive and diuretic action. 5. In all three kinds of hypertensive rats the diuretic activity of DS-511 was similar to that of HC in the excretion of urine and sodium, but the former was less kaliuretic than the latter.

• Authors: Y Inada, K Nishikawa, A Nagaoka, S Kikuchi
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 27 Issue 9 Pg. 1663-9 ( 1977) ISSN: 0004-4172 [Print] Germany
• PMID: 579134 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Diuretics
• Pyridazines
• Hydrochlorothiazide
• Desoxycorticosterone

Topics

• Animals
• Blood Pressure (drug effects)
• Desoxycorticosterone
• Diuretics (pharmacology, therapeutic use)
• Hydrochlorothiazide (pharmacology)
• Hypertension (chemically induced, drug therapy)
• Hypertension, Renal (drug therapy)
• Pyridazines (pharmacology, therapeutic use)
• Rats