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[Determination of gentamicin in the serum of patients with normal renal function with the purpose of avoiding subtherapeutic antibiotic levels (author's transl)].

Abstract
In 24 patients with normal renal function the serum concentration of gentamicin was checked during a period of 3--5 days. The biological test is simple and rapid to perform. The patients were given doses of 80--240 mg gentamicin per day. Even at doses of 240 mg/day no accumulation of the drug occurred. Intramuscular application of an 80 mg maximum dose of gentamicin did not result in any toxic serum concentrations. The measurement of peak concentrations--1 h after application--is therefore jus aimed at correcting too low dosages. The median values of the serum peak concentrations are 4--6 microgram/ml in the case of single dose application of 80 mg and 3 microgram/ml in the case of single dose application of 40 mg. Consequently serum concentrations effective against moderately susceptible bacteria (MIC = 1--4 microgram/ml) do not act for a sufficiently long time, since the half-life for elimination is 2 h. Daily dosages of up to 240 mg (3X80 mg) gentamicin are only effective in infections caused by very susceptible bacteria with a MIC up to 1 microgram/ml.
AuthorsR Bickenbach, W Peitsch, R Ansorg
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 27 Issue 10 Pg. 2023-7 ( 1977) ISSN: 0004-4172 [Print] Germany
Vernacular TitleBestimmung von Gentamicin im Serum nierengesunder Patienten zum Ausschluss subtherapeutischer Wirkstoffspiegel.
PMID579117 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Gentamicins
Topics
  • Dose-Response Relationship, Drug
  • Gentamicins (administration & dosage, blood)
  • Humans
  • Injections, Intramuscular
  • Injections, Intravenous

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