Abstract |
In 24 patients with normal renal function the serum concentration of gentamicin was checked during a period of 3--5 days. The biological test is simple and rapid to perform. The patients were given doses of 80--240 mg gentamicin per day. Even at doses of 240 mg/day no accumulation of the drug occurred. Intramuscular application of an 80 mg maximum dose of gentamicin did not result in any toxic serum concentrations. The measurement of peak concentrations--1 h after application--is therefore jus aimed at correcting too low dosages. The median values of the serum peak concentrations are 4--6 microgram/ml in the case of single dose application of 80 mg and 3 microgram/ml in the case of single dose application of 40 mg. Consequently serum concentrations effective against moderately susceptible bacteria (MIC = 1--4 microgram/ml) do not act for a sufficiently long time, since the half-life for elimination is 2 h. Daily dosages of up to 240 mg (3X80 mg) gentamicin are only effective in infections caused by very susceptible bacteria with a MIC up to 1 microgram/ml.
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Authors | R Bickenbach, W Peitsch, R Ansorg |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 27
Issue 10
Pg. 2023-7
( 1977)
ISSN: 0004-4172 [Print] Germany |
Vernacular Title | Bestimmung von Gentamicin im Serum nierengesunder Patienten zum Ausschluss subtherapeutischer Wirkstoffspiegel. |
PMID | 579117
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Dose-Response Relationship, Drug
- Gentamicins
(administration & dosage, blood)
- Humans
- Injections, Intramuscular
- Injections, Intravenous
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