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[Effect of tibric acid (CP-18.254) on plasma lipids in patients with primary endogenous hyperlipoproteinemia].

Abstract
Tibric acid [CP-18.524; 2-chloro-5-(3,5-dimethyl-piperidino-sulfonyl-benzoic acid], a new hypolipidemic drug was given to 20 patients with primary endogenous hyperlipoproteinemia of type II, III, IV and V Fredrickson in a daily dose of 1.5 g for 1 year. As compared to a 4-week placebo period, the treatment with tibric acid led to a significant decrease in plasma cholesterol in 6 type-II patients (p less than 0.02) and to a significant decrease in plasma cholesterol and triglycerides in 6 type-III patients (p less than 0.001 and p less than 0.001, resp.) and in 4 type-IV patients (p less than 0.001 and p less than 0.001, resp.). No significant effect of tibric acid on plasma lipids was noted in 4 type-V patients. Apart from a moderate nausea in two patients, no side effects occurred.
AuthorsH J Lisch, S Sailer, H Braunsteiner
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 27 Issue 10 Pg. 2017-20 ( 1977) ISSN: 0004-4172 [Print] Germany
Vernacular TitleEffekt von Tibrinsäure (CP-18.524) auf die Plasmalipide von Patienten mit primärer endogener Hyperlipoprotein amie.
PMID579116 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Hypolipidemic Agents
  • Lipids
  • Piperidines
  • Triglycerides
  • Cholesterol
Topics
  • Adult
  • Aged
  • Cholesterol (blood)
  • Drug Evaluation
  • Humans
  • Hyperlipidemias (blood, drug therapy)
  • Hypolipidemic Agents (therapeutic use)
  • Lipids (blood)
  • Middle Aged
  • Piperidines (pharmacology, therapeutic use)
  • Triglycerides (blood)

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