[Obtaining 14-oxycarminomycin and a study of its antitumor activity].

Abstract

The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomycin.

• Authors: L S Povarov, V S Bazhanov, V F Vasekina
• Journal: Antibiotiki (Antibiotiki) Vol. 22 Issue 8 Pg. 693-5 (Aug 1977) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Poluchenie 14-oksikarminomitsina i izuchenie ego protivoopukholevoĭ aktivnosti.
• PMID: 578668 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• 14-oxycarminomycin
• Carubicin

Topics

• Animals
• Antibiotics, Antineoplastic (chemical synthesis)
• Carubicin (analogs & derivatives, chemical synthesis, therapeutic use, toxicity)
• Drug Evaluation
• Hydrolysis
• Lethal Dose 50
• Lymphoma, Non-Hodgkin (drug therapy)
• Mice
• Neoplasms, Experimental (drug therapy)