Peliosis hepatis. Twelve cases associated with oral androgen therapy.

Abstract

Peliosis hepatis was encountered in 12 patients treated with high-dose oxymetholone or fluoxymesterone therapy. In three cases liver failure was the primary cause of death. In one case, the diagnosis was established by biopsy, the androgen therapy was discontinued, and the lesion was absent at autopsy two years later. In eight cases peliosis hepatis was an incidental finding at postmortem examination. The clinical and anatomic features of these cases are described, and previously reported cases of peliosis are briefly reviewed. A hypothesis is offered to explain the association of this peculiar lesion with anabolic androgen therapy.

• Authors: J Nadell, J Kosek
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 101 Issue 8 Pg. 405-10 (Aug 1977) ISSN: 0003-9985 [Print] United States
• PMID: 577673 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fluoxymesterone
• Oxymetholone

Topics

• Adult
• Aged
• Chemical and Drug Induced Liver Injury (etiology, pathology)
• Child, Preschool
• Female
• Fluoxymesterone (adverse effects)
• Hemorrhage
• Humans
• Kupffer Cells (pathology)
• Liver (pathology)
• Lysosomes (ultrastructure)
• Male
• Middle Aged
• Oxymetholone (adverse effects)