Thiamine triphosphate deficiency in subacute necrotizing encephalomyelopathy.

Abstract

Extracts of tissue fluids from a patient with subacute necrotizing encephalomyelopathy inhibit thiamine pyrophosphate-adenosine triphosphate phosphotransferase of rat brain. Brain tissue from the patient, in contrast to normal brain tissue, contained essentially no thiamine triphosphate, although thiamine and its other phosphate esters were present in normal concentrations. These findings suggest a relation between this disease and thiamine triphosphate.

• Authors: J R Cooper, Y Itokawa, J H Pincus
• Journal: Science (New York, N.Y.) (Science) Vol. 164 Issue 3875 Pg. 74-5 (Apr 04 1969) ISSN: 0036-8075 [Print] United States
• PMID: 5773712 (Publication Type: Journal Article)

Chemical References

• Phosphates
• Phosphotransferases
• Thiamine Pyrophosphate
• Thiamine

Topics

• Animals
• Brain (enzymology)
• Brain Diseases (blood, cerebrospinal fluid, genetics, urine)
• Cerebellum (analysis)
• Child
• Child, Preschool
• Frontal Lobe (analysis)
• Humans
• Kidney (analysis)
• Liver (analysis)
• Phosphates (analysis)
• Phosphotransferases
• Rats
• Spinal Cord Diseases (blood, cerebrospinal fluid, genetics, urine)
• Thiamine (analysis)
• Thiamine Deficiency
• Thiamine Pyrophosphate (analysis)