Fatty acids of phospholipids in human neonatal lung surfactant.

Abstract

The fatty acid chains of lecithin, phosphatidyl ethanolamine (PE), and phosphatidyl dimethylethanolamine (PDME) in human neonatal alveolar washes were analyzed. Both alpha- and beta-palmitic acid increased with gestational age on all phospholipids analyzed. No evidence for high concentrations of myristic acid was found on any phospholipid. Babies who were stillborn or who had died of hyaline membrane disease (HMD) had lower proportions of beta-lecithin palmitic acid when compared with babies who breathed normally before death. In the HMD group these levels were significantly lower.

• Authors: C E Parkinson, D R Harvey, J Pryse-Davies
• Journal: Pediatric research (Pediatr Res) Vol. 11 Issue 6 Pg. 723-7 (Jun 1977) ISSN: 0031-3998 [Print] United States
• PMID: 577303 (Publication Type: Journal Article)

Chemical References

• Fatty Acids
• Myristic Acids
• Oleic Acids
• Palmitic Acids
• Phosphatidylcholines
• Phosphatidylethanolamines
• Phospholipids
• Pulmonary Surfactants
• Stearic Acids

Topics

• Fatty Acids (analysis)
• Humans
• Hyaline Membrane Disease (metabolism)
• Infant, Newborn
• Myristic Acids (analysis)
• Oleic Acids (analysis)
• Palmitic Acids (analysis)
• Phosphatidylcholines (analysis)
• Phosphatidylethanolamines (analysis)
• Phospholipids (analysis)
• Pulmonary Surfactants (analysis)
• Stearic Acids (analysis)