Aspirin- and bile- induced acute erosive gastritis: its prevention by metiamide therapy.

Abstract

Aspirin or bile administered by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion.

• Authors: N S Mann, A J Sachdev
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 101 Issue 4 Pg. 206-7 (Apr 1977) ISSN: 0003-9985 [Print] United States
• PMID: 576788 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Bile Acids and Salts
• Metiamide
• Thiourea
• Aspirin

Topics

• Acute Disease
• Animals
• Aspirin (adverse effects)
• Bile Acids and Salts (adverse effects)
• Gastric Mucosa (pathology)
• Gastritis (chemically induced, pathology, prevention & control)
• Male
• Metiamide (therapeutic use)
• Rats
• Thiourea (analogs & derivatives)