Kidney lesions induced in rats by p-aminophenol.

Abstract

Necrosis of the terminal third of the proximal convulated tubule develops in rats after a single intravenous injection of p-aminophenol hydrochloride. As the tubules regenerate a chronic inflammatory reaction occurs in the interstitial tissue, and this reaction extends beyond the original zone of injury. These findings are additional evidence that some aromatic compounds are selectively nephrotoxic and may be particularly relevant to the problem of renal damage associated with heavy and prolonged doses of analgesics.

• Authors: C R Green, K N Ham, J D Tange
• Journal: British medical journal (Br Med J) Vol. 1 Issue 5637 Pg. 162-4 (Jan 18 1969) ISSN: 0007-1447 [Print] England
• PMID: 5762279 (Publication Type: Journal Article)

Chemical References

• Aniline Compounds
• Phenols

Topics

• Aniline Compounds
• Animals
• Female
• Injections, Intravenous
• Kidney Cortex Necrosis (chemically induced, pathology)
• Kidney Tubules (drug effects, pathology)
• Nephritis, Interstitial (chemically induced, pathology)
• Phenols
• Rats