An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat.

Abstract

The distribution and the size of lesions evoked in rat heart by the injection of isoprenaline 30 mg/kg have been estimated in rat pretreated or not by various dosages of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate). It has been observed that the number of lesions was inequally distributed in the various parts of the heart. Creatinol O-phosphate pretreatment reduced both the number and the size of the reactive areas. The reduction of the number of foci was dose-dependent. The action of the lowest creatinol O-phosphate doses was increased by a pretreatment during 4 days instead of the 4 h pretreatment initially used. The size of the reactive area was also reduced but in a manner indicating an action of large creatinol O-phosphate dosages on the microcirculation. It is concluded that, due to its protective action against cardionecrosis, creatinol O-phosphate has great potential value in patients with myocardial infarction in whom the extent of the infarct size may be limited by an action on the jeopardized area.

• Authors: T Godfraind, X Sturbois
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 9a Pg. 1457-64 ( 1979) ISSN: 0004-4172 [Print] Germany
• PMID: 575492 (Publication Type: Journal Article)

Chemical References

• creatinol phosphate
• Isoproterenol
• Creatine

Topics

• Animals
• Cardiomyopathies (chemically induced, prevention & control)
• Coronary Circulation (drug effects)
• Creatine (analogs & derivatives, pharmacology)
• Isoproterenol (antagonists & inhibitors, toxicity)
• Male
• Microcirculation (drug effects)
• Myocardium (pathology)
• Necrosis (chemically induced, pathology)
• Rats