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An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat.

Abstract
The distribution and the size of lesions evoked in rat heart by the injection of isoprenaline 30 mg/kg have been estimated in rat pretreated or not by various dosages of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate). It has been observed that the number of lesions was inequally distributed in the various parts of the heart. Creatinol O-phosphate pretreatment reduced both the number and the size of the reactive areas. The reduction of the number of foci was dose-dependent. The action of the lowest creatinol O-phosphate doses was increased by a pretreatment during 4 days instead of the 4 h pretreatment initially used. The size of the reactive area was also reduced but in a manner indicating an action of large creatinol O-phosphate dosages on the microcirculation. It is concluded that, due to its protective action against cardionecrosis, creatinol O-phosphate has great potential value in patients with myocardial infarction in whom the extent of the infarct size may be limited by an action on the jeopardized area.
AuthorsT Godfraind, X Sturbois
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 9a Pg. 1457-64 ( 1979) ISSN: 0004-4172 [Print] GERMANY, WEST
PMID575492 (Publication Type: Journal Article)
Chemical References
  • creatinol phosphate
  • Isoproterenol
  • Creatine
Topics
  • Animals
  • Cardiomyopathies (chemically induced, prevention & control)
  • Coronary Circulation (drug effects)
  • Creatine (analogs & derivatives, pharmacology)
  • Isoproterenol (antagonists & inhibitors, toxicity)
  • Male
  • Microcirculation (drug effects)
  • Myocardium (pathology)
  • Necrosis (chemically induced, pathology)
  • Rats

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