An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat.

The distribution and the size of lesions evoked in rat heart by the injection of isoprenaline 30 mg/kg have been estimated in rat pretreated or not by various dosages of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate). It has been observed that the number of lesions was inequally distributed in the various parts of the heart. Creatinol O-phosphate pretreatment reduced both the number and the size of the reactive areas. The reduction of the number of foci was dose-dependent. The action of the lowest creatinol O-phosphate doses was increased by a pretreatment during 4 days instead of the 4 h pretreatment initially used. The size of the reactive area was also reduced but in a manner indicating an action of large creatinol O-phosphate dosages on the microcirculation. It is concluded that, due to its protective action against cardionecrosis, creatinol O-phosphate has great potential value in patients with myocardial infarction in whom the extent of the infarct size may be limited by an action on the jeopardized area.
AuthorsT Godfraind, X Sturbois
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 9a Pg. 1457-64 ( 1979) ISSN: 0004-4172 [Print] GERMANY, WEST
PMID575492 (Publication Type: Journal Article)
Chemical References
  • creatinol phosphate
  • Isoproterenol
  • Creatine
  • Animals
  • Cardiomyopathies (chemically induced, prevention & control)
  • Coronary Circulation (drug effects)
  • Creatine (analogs & derivatives, pharmacology)
  • Isoproterenol (antagonists & inhibitors, toxicity)
  • Male
  • Microcirculation (drug effects)
  • Myocardium (pathology)
  • Necrosis (chemically induced, pathology)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: