The management of the patient with
mycosis fungoides requires a variety of therapeutic modalities depending on the stage of the disease. Topically applied
nitrogen mustard in the early stages of the disease has a beneficital palliative effect. The effects of
nitrogen mustard paintings in the later course of the disease have not been previously reported. In the present study, topically applied
nitrogen mustard solution was used to control recurrences of
mycosis fungoides following electron beam
therapy in 11 patients. Each patient received whole body applications of freshly prepared 10 mg per 50 ml
solution of
mechlorethamine hydrochloride (a
nitrogen mustard) in water daily for seven days. In all patients
pruritus disappeared within the first week and
ulcers and plaques improved or disappeared in two to four weeks. The seven-day courses of
mechlorethamine paintings were repeated as recurrences were noted.
Mycosis fungoides was controlled by this
therapy for periods ranging up to 15 months. Absence of systemic toxicity, a low incidence of cutaneous irritation and application of the treatments at home make topical
nitrogen mustard a useful adjunct in the management of the late stages of
mycosis fungoides.