Long term effect of teflutixol on apomorphine-induced stereotypy and vomiting in dogs.

Abstract

Dose--response relationships to apomorphine-induced vomiting and stereotyped running behaviour have been determined in dogs before, and up to 24 and 28 days respectively, after daily oral treatment with 2.5 mg/kg of teflutixol or 12 days. The ED50 values for apomorphine-induced vomiting after teflutixol were not different from those obtained before treatment. Stereotyped running behaviour of increasing intensity was seen 4--12 days after teflutixol treatment. The intensity then declined and returned to normal. The results suggest that the nigro-neostriatal dopamine system in dogs became hypersensitive after prolonged teflutixol treatment, while the dopamine receptors of the emetic chemotrigger zone did not.

• Authors: O Svendsen
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 53 Issue 4 Pg. 387-90 (Feb 01 1979) ISSN: 0014-2999 [Print] Netherlands
• PMID: 570504 (Publication Type: Journal Article)

Chemical References

• Thioxanthenes
• Apomorphine

Topics

• Animals
• Apomorphine (antagonists & inhibitors)
• Behavior (drug effects)
• Dogs
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Stereotyped Behavior (drug effects)
• Thioxanthenes (pharmacology)
• Vomiting (chemically induced)