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Antagonism of reserpine-induced emesis in pigeons: a screening method for antidepressant activity.

Abstract
1. Various antidepressant drugs and procedures have been studied against reserpine-induced emesis in pigeons.2. Electroconvulsions, pentylenetetrazol and a non-hydrazide monoamine oxidase inhibitor (pargyline) block reserpine emesis.3. It is suggested that reserpine-induced emesis in pigeons provides a simple and reliable method for studying anti-reserpine activity, and the compounds effective in antagonizing this emetic response are likely to have antidepressant property.
AuthorsK N Dhawan, G P Gupta, B P Jaju
JournalBritish journal of pharmacology (Br J Pharmacol) Vol. 34 Issue 2 Pg. 248-50 (Oct 1968) ISSN: 0007-1188 [Print] England
PMID5687584 (Publication Type: Journal Article)
Chemical References
  • Antidepressive Agents
  • Insulin
  • Monoamine Oxidase Inhibitors
  • Reserpine
  • Pargyline
  • Pentylenetetrazole
Topics
  • Animals
  • Antidepressive Agents (pharmacology)
  • Columbidae
  • Electroshock
  • Insulin (pharmacology)
  • Monoamine Oxidase Inhibitors (pharmacology)
  • Pargyline (pharmacology)
  • Pentylenetetrazole (pharmacology)
  • Reserpine (antagonists & inhibitors)
  • Vomiting (chemically induced)

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