Abstract |
1 Self-stimulation to lever pressing and capacitance probe touching was obtained in Mongolian gerbils (Meriones unguiculatus) from electrode placements within the medial forebrain bundle. 2 Lever pressing was more sensitive to the decremental effects of a central depressant, pentobarbitone, than capacitance probe touching, suggesting its greater responsiveness to disturbances of motor function. 3 Spiperone (0.005 to 0.05 mg/kg) attenuated capacitance probe touching and lever pressing equally, a finding explained by action on either reward pathways or on the ability to initiate responding. 4 This same dose range of spiperone (0.005 to 0.05 mg/kg) attenuated locomotor activity, whether spontaneous or evoked by non-contingent electrical stimulation, and produced catalepsy. 5 The spiperone-induced attentuation of self-stimulation was not necessarily a result of its action on dopaminergic reward pathways since the effects could equally well be explained by a failure to initiate responding.
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Authors | N Francis, E Marley, J D Stephenson |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 63
Issue 1
Pg. 43-9
(May 1978)
ISSN: 0007-1188 [Print] England |
PMID | 565659
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Butyrophenones
(pharmacology)
- Catalepsy
(chemically induced)
- Conditioning, Operant
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Gerbillinae
- Humans
- Motor Activity
(drug effects)
- Self Stimulation
(drug effects)
- Spiperone
(pharmacology)
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