Abstract |
The action of two preparations (I and II) of antibiotic Wr 142 FPG on development of Ehrlich carcinoma, Nemeth-Kellner lymphoma and leukemias L 1210 and P 388 was studied. Preparation I injected s.c. daily during 14 days in doses of 10 mg/kg (1/25 LD50) inhibited growth of Ehrlich carcinoma and Nemeth-Kellner lymphoma subcutaneous tumors in R 3 mice by about 70%. The same preparation in a single i.p. injection (10 mg/kg) in FDF1 mice distinctly prolonged survival of mice inoculated with L 1210 leukemia, but was without effect on P 388 leukemia. Preparation II inhibited growth of solid tumors in doses as low as 0.1-0.2 mg/kg (about 65% inhibition), but in the same doses was ineffective against leukemias L 1210 and P 388 in CDF1 mice.
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Authors | M Mordarski, J Wieczorek |
Journal | Archivum immunologiae et therapiae experimentalis
(Arch Immunol Ther Exp (Warsz))
Vol. 25
Issue 6
Pg. 757-64
( 1977)
ISSN: 0004-069X [Print] Switzerland |
PMID | 565628
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
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Topics |
- Animals
- Antibiotics, Antineoplastic
(isolation & purification, therapeutic use)
- Carcinoma, Ehrlich Tumor
(drug therapy)
- Leukemia
(drug therapy)
- Leukemia L1210
(drug therapy)
- Lymphoma
(drug therapy)
- Neoplasms
(drug therapy)
- Streptomyces
(metabolism)
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