Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii.

Abstract

Bioassay-guided fractionation of the aqueous alcoholic extract of the marine sponge Verongia spengelii for tumor inhibitory agents led to the isolation of aplysinopsin, a new tryptophan derivative recently reported from another sponge Thorecta aplysinopsis. Aplysinopsin showed cytotoxicity against the KB, P388 and L1210 cell cultures.

• Authors: K H Hollenbeak, F J Schmitz
• Journal: Lloydia (Lloydia) 1977 Sep-Oct Vol. 40 Issue 5 Pg. 479-81 ISSN: 0024-5461 [Print] United States
• PMID: 562965 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Cytotoxins
• aplysinopsin
• Tryptophan

Topics

• Animals
• Antineoplastic Agents
• Cell Line
• Cytotoxins
• Leukemia L1210
• Porifera (analysis)
• Tryptophan (analogs & derivatives, isolation & purification)