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Monozygotic twins concordant for tracheo-esophageal fistula and discordant for the VATER association.

Abstract
Monozygotic female twins were concordant for tracheo-esophageal fistula (TEF); and one twin also manifested other anomalies in the VATER association, including agenesis of the female reproductive tract. Review of the literature discloses a familial tendency for recurrence of TEF and a high concordance rate in monozygotic twins, indicating a significant genetic influence for the isolated anomaly. In the case of the VATER association, the sporadic occurrence of affected individuals and discordance in twins implicates the effect of non-genetic factors.
AuthorsS L King, R L Ladda, S J Shochat
JournalActa paediatrica Scandinavica (Acta Paediatr Scand) Vol. 66 Issue 6 Pg. 783-5 (Nov 1977) ISSN: 0001-656X [Print] Sweden
PMID562588 (Publication Type: Case Reports, Journal Article)
Topics
  • Abnormalities, Multiple (genetics)
  • Anus, Imperforate (genetics)
  • Diseases in Twins
  • Esophagus (abnormalities)
  • Female
  • Humans
  • Infant, Newborn
  • Kidney (abnormalities)
  • Pregnancy
  • Radius (abnormalities)
  • Spinal Cord (abnormalities)
  • Tracheoesophageal Fistula (genetics)
  • Twins, Monozygotic
  • Vagina (abnormalities)

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