Abstract |
Monozygotic female twins were concordant for tracheo-esophageal fistula (TEF); and one twin also manifested other anomalies in the VATER association, including agenesis of the female reproductive tract. Review of the literature discloses a familial tendency for recurrence of TEF and a high concordance rate in monozygotic twins, indicating a significant genetic influence for the isolated anomaly. In the case of the VATER association, the sporadic occurrence of affected individuals and discordance in twins implicates the effect of non-genetic factors.
|
Authors | S L King, R L Ladda, S J Shochat |
Journal | Acta paediatrica Scandinavica
(Acta Paediatr Scand)
Vol. 66
Issue 6
Pg. 783-5
(Nov 1977)
ISSN: 0001-656X [Print] Sweden |
PMID | 562588
(Publication Type: Case Reports, Journal Article)
|
Topics |
- Abnormalities, Multiple
(genetics)
- Anus, Imperforate
(genetics)
- Diseases in Twins
- Esophagus
(abnormalities)
- Female
- Humans
- Infant, Newborn
- Kidney
(abnormalities)
- Pregnancy
- Radius
(abnormalities)
- Spinal Cord
(abnormalities)
- Tracheoesophageal Fistula
(genetics)
- Twins, Monozygotic
- Vagina
(abnormalities)
|