Dose-response relationships in attenuation of puromycin-induced amnesia by neurohypophyseal peptides.

Abstract

Intracerebral injections of puromycin one day after training of mice in a Y-maze cause amnesia when the animals are tested 7 days later. This amnesia was shown to be attenuated by various neurohypophyseal hormones, analogs and fragments, administered subcutaneously immediately after training. Dose-response relationships have been obtained for the attenuation of puromycin-induced amnesia in mice by selected neurohypophyseal peptides. All of the compounds tested reduce the amnesia in a dose-related way, suggesting that these peptides may interact with specific receptors to induce their central effect. Among the peptides studied the two most potent--i.e., those that cause substantial retention of memory at the lowest doses--are the neurohypophyseal hormone arginine vasopressin and Z-prolyl-leucyl-glycinamide (Z-MIF).

• Authors: J B Flexner, L B Flexner, P L Hoffman, R Walter
• Journal: Brain research (Brain Res) Vol. 134 Issue 1 Pg. 139-44 (Sep 23 1977) ISSN: 0006-8993 [Print] Netherlands
• PMID: 562219 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Peptides
• Receptors, Drug
• Arginine Vasopressin
• Puromycin

Topics

• Amnesia (chemically induced, drug therapy)
• Animals
• Arginine Vasopressin (pharmacology)
• Dose-Response Relationship, Drug
• Humans
• Mice
• Peptides (pharmacology)
• Pituitary Gland, Posterior
• Puromycin (pharmacology)
• Receptors, Drug (drug effects)