[Behavioral effects of 5-(o-chlorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (ID-690)].

Abstract

Effects on the central nervous system of ID-690, a new benzodiazepine derivative were investigated and compared mainly with those of diazepam in mice and rats. Locomotor activity of the rat was increased with ID-690, at doses of 2 approximately 5 mg/kg p.o., as with diazepam. ID-690 was approximately 5 times more potent than diazepam in inhibiting fighting behavior of long-term isolated mice. Hyperemotionality induced by either septal lesions or olfactory bulbectomy was also inhibited by ID-690. This effect was almost the same in potency as that of diazepam. ID-690 was only 1/30 as potent as diazepam in preventing maximal electroshock convulsion, while it was approximately 18 times more potent that diazepam in suppressing pentetrazol convulsion in mice. ID-690 was approximately 5 times as potent as diazepam in impairing rotarod performance in mice. The muscle relaxant effect of ID-690 was approximately 10 times as potent as diazepam, as measured with an inclined screen test in mice. Thus the effect of ID-690, as compared with diazepam, was characterized by its relatively potent muscle relaxant and extremely potent anti-pentetrazol convulsant action.

• Authors: S Ueki, Y Gomita, Y Ataki, K Yamada, H Yoshimura
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 73 Issue 2 Pg. 243-55 (Mar 1977) ISSN: 0015-5691 [Print] Japan
• PMID: 560343 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Benzodiazepinones
• Clonazepam
• Nitrazepam
• Diazepam

Topics

• Agonistic Behavior (drug effects)
• Animals
• Anticonvulsants
• Behavior, Animal (drug effects)
• Benzodiazepinones (pharmacology)
• Clonazepam (analogs & derivatives, pharmacology)
• Diazepam (pharmacology)
• Dose-Response Relationship, Drug
• Electroshock
• Emotions (drug effects)
• Locomotion (drug effects)
• Male
• Mice
• Motor Activity (drug effects)
• Nitrazepam (pharmacology)
• Olfactory Bulb (surgery)
• Rats
• Septal Nuclei (surgery)
• Social Isolation