Pharmacological effects of topical application of
Shiunko, a main prescription of Shikon (Lithospermum Officinale Linńe var. erythrorhizon Maximowicz), were studied in comparison with that of
ether extracts of Shikon and Tooki.
Ointment of Shikon
ether extract (50 mg/site) inhibited markedly an increased vascular permeability and acute
edema induced by
histamine,
serotonin,
bromelain, anti-rat rabbit serum and heat. It also inhibited an increase of local cutaneous temperature induced by phlogistic stimulation (ultraviolet irradiation and heat). On the other hand, it accelerated wound healing in rats. The activity of Shikon
ether extract on inflammatory reaction was the most potent in 0.2 approximately 0.1% of
ointment concentration and was diminished in higher or lower concentrations. Tooki extract inhibited slightly an acute inflammatory reaction, but had no effect on increase of cutaneous temperature and wound healing in rats.
Shiunko contains about 0.2% of Shikon and 0.04% of Tooki extract. The effect of
Shiunko was similar to that of Shikon
ether extract, but the activity was slightly more potent than that of Shikon.
Shiunko inhibited rubor, calor and
tumor in acute inflammatory reaction and promoted wound healing. Furthermore, it was reported that pigments of Shikon have
antibiotic activity. The results suggest that
Shiunko is an effective
ointment for cutaneous
injuries.