Toxicologic and teratologic studies of oxibendazole in ruminants and laboratory animals.

Abstract

Acute toxicity of oxibendazole was assessed with single oral doses given to mice (4 to 32 g/kg of body weight), sheep (230 to 600 mg/kg), and cattle (600 mg/kg); there were no ill effects. Subacute toxicity did not occur with multiple doses given 5 days to cattle (30 to 75 mg/kg/day) and to sheep (10 to 50 mg/kg/day). Chronic effects did not occur with daily doses of 3 to 30 mg/kg given 98 days to rats and dogs. Teratogenicity of the compound was studied in mice, rats, and sheep medicated at a dose level of 30 mg of oxibendazole/kg and in cattle given 75 mg/kg on selected dates during pregnancy. Microscopically, rodent fetuses seemed normal, and on gross physical examination, lambs and calves were free of malformations and ossification variations.

• Authors: V J Theodorides, C J DiCuollo, T Nawalinski, C R Miller, J R Murphy, J F Freeman, J C Killeen Jr, W R Rapp
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 38 Issue 6 Pg. 809-14 (Jun 1977) ISSN: 0002-9645 [Print] United States
• PMID: 560153 (Publication Type: Journal Article)

Chemical References

• Benzimidazoles
• Carbamates
• Teratogens
• oxibendazole
• Aspartate Aminotransferases
• Cholinesterases

Topics

• Abnormalities, Drug-Induced (veterinary)
• Animals
• Aspartate Aminotransferases (blood)
• Benzimidazoles (toxicity)
• Carbamates (toxicity)
• Cattle
• Cattle Diseases (chemically induced)
• Cholinesterases (blood)
• Dogs
• Female
• Male
• Mice
• Osteogenesis
• Pregnancy
• Rats
• Sheep
• Sheep Diseases (chemically induced)
• Teratogens