Effect of chlorite-oxidized oxyamylose on influenza virus infection in mice.

Abstract

Intraperitoneally administered chlorite-oxidized oxyamylose (COAM) provided protection of mice against intranasal infection with several influenza virus strains. Treated animals invariably showed a reduced consolidation of the lungs and, in the case of infection with lethal strains of virus, also a delay in mortality. With a small dose of influenza A/PR8 virus, an increase in final survival rate could be observed. The effect of COAM on influenza virus infection lasted for at least 4 to 8 days. Inhibition of lung consolidation was not paralleled by a decrease in virus multiplication in the lung. The significance of this finding in relation to the mechanism of the antiviral action of COAM is discussed.

• Authors: A Billiau, J J Muyembe, P De Somer
• Journal: Applied microbiology (Appl Microbiol) Vol. 21 Issue 4 Pg. 580-4 (Apr 1971) ISSN: 0003-6919 [Print] United States
• PMID: 5575564 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Carboxylic Acids
• Hemagglutinins, Viral
• Polysaccharides
• Chlorine

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Carboxylic Acids (therapeutic use)
• Chlorine
• Disease Models, Animal
• Female
• Hemagglutinins, Viral (analysis)
• Injections, Intraperitoneal
• Lung (microbiology, pathology)
• Mice
• Orthomyxoviridae (drug effects, growth & development, isolation & purification)
• Orthomyxoviridae Infections (microbiology, mortality, pathology, prevention & control)
• Oxidation-Reduction
• Polysaccharides
• Species Specificity
• Time Factors
• Virus Replication (drug effects)