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Uptake and release of 14 C-5-hydroxytryptamine by platelets in affective illness.

Abstract
In the search for paradigms of postulated abnormalities in indolamine function in the brain in affective disorders, 5-HT uptake and release was estimated in platelets from patients suffering from severe depressive illness. Neither of these measures was altered by the illness and the most likely explanation for the negative findings was that in this setting platelets are not a suitable model.
AuthorsD M Shaw, D A MacSweeney, N Woolcock, A B Bevan-Jones
JournalJournal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 34 Issue 3 Pg. 224-5 (Jun 1971) ISSN: 0022-3050 [Print] England
PMID5571308 (Publication Type: Journal Article)
Chemical References
  • Amines
  • Carbon Isotopes
  • Indoles
  • Serotonin
Topics
  • Amines (metabolism)
  • Blood Platelets (metabolism)
  • Brain (metabolism)
  • Carbon Isotopes
  • Depression (blood)
  • Humans
  • In Vitro Techniques
  • Indoles (metabolism)
  • Models, Neurological
  • Neurons (metabolism)
  • Serotonin (metabolism)

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