Development of hemangiosarcomas in B6C3F1 mice fed 2-methyl-1-nitroanthraquinone.

Abstract	Subcutaneous hemangiosarcomas developed in 97% of 172 B6C3F1 mice of both sexes fed either 0.03% or 0.36% 2-methyl-1-nitroanthraquinone in the diet. There was no significant relationship to dose or sex. In addition similar vascular tumors occurred in the mesentery of 14 mice. 2-Methyl-1-nitroanthraquinone is carcinogenic in B6C3F1 mice when given in food. One of 97 control mice had a splenic hemangiosarcoma.
Authors	A S Krishna Murthy, J R Baker, E R Smith, G G Wade
Journal	International journal of cancer (Int J Cancer) Vol. 19 Issue 1 Pg. 117-21 (Jan 1977) ISSN: 0020-7136 [Print] United States
PMID	556715 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anthraquinones 2-methyl-1-nitroanthraquinone
Topics	Animals Anthraquinones (administration & dosage) Dose-Response Relationship, Drug Female Hemangiosarcoma (chemically induced, pathology) Lung Neoplasms (pathology) Male Mesentery (pathology) Mice Mice, Inbred Strains Muscles (pathology) Neoplasm Metastasis Sex Factors

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