[Doses levorin display an antiandrogenic action?].

Abstract

The antiandrogenic effect of levorin on immature castrated rats treated with exogenic testosterone was studied. In a dose of 200 mg/kg levorin lowered the cholesterin blood levels in the rats, inhibited the testosterone-induced increase in RNA concentration in the ventral and dorsal prostate and the seminal vesicles and to a less extent suppressed the growth of the accessory sexual glands. However, the antiandrogenic effect was observed with the use of levorin in the dose producing a pronounced toxic action evident from death of a part of the animals and a marked decrease in the animal body weight. This fact casts doubt on specificity of the levorin effect. Apparently, in high doses levorin impairs metabolism as a whole which cannot but affect the response of the sexual glands to administration of testosterone.

• Authors: T S Kharitonenko, E B Lishnevskaia, I V Shneĭ, I A Sizova, G A Mikhaĭlets
• Journal: Antibiotiki (Antibiotiki) Vol. 24 Issue 10 Pg. 772-6 (Oct 1979) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Okazyvaet li levorin antiandrogennoe deĭstvie?
• PMID: 556230 (Publication Type: English Abstract, Journal Article)

Chemical References

• Androgen Antagonists
• Antifungal Agents
• Candicidin
• Testosterone
• RNA
• DNA
• Cholesterol

Topics

• Androgen Antagonists
• Animals
• Antifungal Agents (pharmacology)
• Candicidin (pharmacology)
• Castration
• Cholesterol (blood)
• DNA (metabolism)
• Dose-Response Relationship, Drug
• Male
• Organ Size (drug effects)
• Prostate (drug effects)
• RNA (metabolism)
• Rats
• Seminal Vesicles (drug effects)
• Testosterone (pharmacology)
• Time Factors