[Histoenzymatic reactions in the cells of the reticuloendothelial system of the liver and spleen and hepatocytes in acute Morfamquat dichloride poisoning].
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| Abstract |
Histoenzymatic changes in cells of the reticulo-endothelial system of liver and spleen and in hepatocytes were studied in the course of acute poisoning with Morfamquat dichloride, without and under the screen of vitamin E (to mice tissue restrictive respiration compound). This herbicide was given to mice in single, intraperitoneal injection of 100 mg/kg b.w. The choice of the enzymes was based on the so-called markers of the lysosomes structures of a cell (acid phosphatase-APh-EC. 3.1.3.2. and beta-glucuronidase-beta-GU-EC. 3.2.1.31) and Golgi apparatus (thiamin pyrophosphatase-TPP-EC. 3.5.99.2) It was stated that Morfamquat dichloride caused clear stimulation in the reticuloendothelial system of the organism, with occurrence of the high activity of APh and beta-GU in the lysosome and phagolysosome structures, growth of the lysosome membranes permeability and passing their content to cytoplasm. Furthermore, the increased activity of TPP-ase in Golgi apparatus hepatocytes of animals liver may point to disturbances of the pirogroniam decarboxylation and also to disturbances of the pentose-phosphate cycle. The application of vitamin E to mice for 5 days before the poisoning, protects animals distinctly against the toxic activity of the herbicide.
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| Authors | C Kaszubkiewicz, J A Madej |
| Journal | Polskie archiwum weterynaryjne (Pol Arch Weter) Vol. 22 Issue 1 Pg. 61-9 ( 1979) ISSN: 0079-3647 [Print] Poland |
| Vernacular Title | Odczyny histoenzymatyczne w komórkach układu siateczkowo-śródbłonkowego watroby i śledziony oraz hepatocytach w przebiegu ostrego zatrucia Morfamquatem dichloride. |
| PMID | 554986 (Publication Type: English Abstract, Journal Article) |
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