Effects of oxyamylose and polyacrylic acid on foot-and-mouth disease and hog cholera virus infections.

Abstract

Two interferon-inducing polycarboxylates were tested for antiviral activity on foot-and-mouth disease (FMD) virus infections in mice, guinea pigs, and swine. Polyacrylic acid, given intraperitoneally, had a protective effect on infection by FMD virus administered in the peritoneal cavity of mice and in the foot pad of guinea pigs. Chlorite-oxidized oxyamylose (COAM) was effective in mice at a dosage of 2 mg/kg. Swine were not protected against naturally transmitted FMD by 120 mg/kg of COAM nor by polyacrylic acid. Swine were not totally unresponsive to COAM since it delayed symptoms of hog cholera. Interferon was not detected in the serum of COAM-treated swine. With FMD virus, an example was found of activity of interferon inducers in experimental hosts and lack of activity in a natural host.

• Authors: J Leunen, J Desmyter, P De Somer
• Journal: Applied microbiology (Appl Microbiol) Vol. 21 Issue 2 Pg. 203-8 (Feb 1971) ISSN: 0003-6919 [Print] United States
• PMID: 5544281 (Publication Type: Journal Article)

Chemical References

• Acrylates
• Antibodies
• Antiviral Agents
• Polymers
• Polysaccharides
• Interferons

Topics

• Acrylates (administration & dosage, therapeutic use)
• Animals
• Antibodies (analysis)
• Antiviral Agents (administration & dosage, therapeutic use)
• Aphthovirus (drug effects)
• Classical Swine Fever (blood, immunology, mortality, prevention & control)
• Disease Models, Animal
• Female
• Fluorescent Antibody Technique
• Foot-and-Mouth Disease (blood, immunology, mortality, prevention & control)
• Guinea Pigs
• Injections, Intraperitoneal
• Injections, Subcutaneous
• Interferons (blood)
• Male
• Mice
• Neutralization Tests
• Oxidation-Reduction
• Polymers (administration & dosage, therapeutic use)
• Polysaccharides (administration & dosage, therapeutic use)
• Swine
• Viruses, Unclassified (drug effects)