Small intestinal changes in enterocolitis complicating Hirschsprung's disease.

Abstract

Hirschsprung's disease is one of the more common causes of childhood bowel obstruction. The disease can cause enterocolitis which, untreated, may result in considerable mortality. We describe our evaluation of two infants who suffered from intractable diarrhea of infancy secondary to Hirschsprung's disease. We found that mucosal damage to the small bowel and disaccharidase deficiency are among the most important mechanisms producing this complications. Therefore, management of enterocolitis including parenteral alimentation should proceed as soon as the complication is observed.

• Authors: D Branski, E Lebenthal
• Journal: Journal of clinical gastroenterology (J Clin Gastroenterol) Vol. 1 Issue 3 Pg. 237-40 (Sep 1979) ISSN: 0192-0790 [Print] United States
• PMID: 553100 (Publication Type: Case Reports, Journal Article)

Chemical References

• Disaccharidases

Topics

• Biopsy
• Disaccharidases (deficiency)
• Enterocolitis, Pseudomembranous (etiology, pathology)
• Female
• Humans
• Infant
• Infant, Newborn
• Intestinal Mucosa (enzymology, pathology)
• Intestine, Small (enzymology, pathology)
• Jejunum (enzymology, pathology)
• Male
• Megacolon (complications)