Evidence of epoxide hydrase activity in human intestinal microflora.

Abstract

Cholesterol-5 alpha, 6 alpha-epoxide has been implicated as an etiologic agent in human colon cancer. The epoxide is metabolized by human intestinal microflora to a product which was characterized by thin-layer and gas-liquid chromatography as well as combined gas-liquid chromatography-mass spectrometry. Chromatographic properties are identical with authentic cholestan-3 beta, 5 alpha, 6 beta-triol, and these results suggest that microbial epoxide hydrase activity is present in the human colon.

• Authors: K K Hwang, M I Kelsey
• Journal: Cancer biochemistry biophysics (Cancer Biochem Biophys) Vol. 3 Issue 1 Pg. 31-5 ( 1978) ISSN: 0305-7232 [Print] England
• PMID: 552896 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cholestanols
• cholestane-3,5,6-triol
• cholesterol alpha-oxide
• Cholesterol
• Epoxide Hydrolases

Topics

• Cholestanols (metabolism)
• Cholesterol (analogs & derivatives, metabolism)
• Chromatography, Thin Layer
• Colon (microbiology)
• Enterobacteriaceae (metabolism)
• Epoxide Hydrolases (metabolism)
• Feces (microbiology)
• Gas Chromatography-Mass Spectrometry
• Humans